Research & Development
The Company, through its wholly owned subsidiary Skinvisible Pharmaceuticals, Inc. conducts in-house research, development and testing of its Invisicare® polymer delivery vehicles, and a variety of compositions which incorporate them. In addition, where appropriate for validation and independent verification of marketing claims, it utilizes FDA registered independent laboratories with extensive qualifications for carrying out investigative product studies, utilizing protocols incorporating Good Lab Practice and Good Clinical Practice ("GLP/GCP") standards.
To date, through recognized independent laboratories, Skinvisible has extensively tested antibacterial/antimicrobial compositions which incorporate Invisicare® and utilize the active ingredient Triclosan 1%. Tests undertaken include:
- Persistence (Duration of Action);
- Adherence to Skin's External Surface;
- Desorption Studies;
- Atomic Force Microscopy;
- Permeation Studies;
- Safety & Skin Sensitivity;
- Skin Moisturizing Ability;
- Antimicrobial Efficacy;
- Toxicology; and
- Product Stability & Aged Product Bio-Activity.
Clinical tests performed by Suncare Research Laboratories in Winston Salem, NC revealed that Skinvisible's sunscreen composition, developed with an Invisicare® polymer delivery vehicle, produced successful results which allow labeling as "Very Water Resistant with an SPF of 30" in accordance with FDA Final Sunscreen Monograph requirements. Under the Monograph the labeled SPF (Sun Protection Factor) of a "Very Water Resistant" sunscreen product is the "largest whole number that is excluded by a 95% confidence interval for the mean SPF after 80 minutes of water immersion." Skinvisible's sunscreen formulation combines water soluble and insoluble polymers without requiring conventional sunscreen delivery ingredients such as petrolatum, silicones or waxes.
Skinvisible has developed various products utilizing Invisicare® for sunless tanning, including sprays (both clear and bronzer) for airbrush tanning. The sunless tanning products all contain Dihydroxyacetone (DHA) as their active ingredient. When delivered topically, DHA absorbs safely into the epidermis producing a natural bronzed tan, free from the effects caused by over-exposure to the suns harmful rays. The spray with bronzer offers an instant bronze color while waiting for the DHA, which typically takes 4 hours to begin bronzing the skin.
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